Sean Taverna Receives Mentor of the Year Award
Dr. Sean Taverna was recently awarded the 2011 Mentor of the Year award from the JHU Graduate Student Association. He addressed the student body June 20th with a talk Memories of Mentors and Methylation.
Scientists Map Epigenetic Changes During Blood Cell Differentiation
Having charted the occurrence of a common chemical change that takes place while stem cells decide their fates and progress from precursor to progeny, a Johns Hopkins-led team of scientists has produced the first-ever epigenetic landscape map for tissue differentiation.
Understanding how the information in the human genome is utilized is one of the central questions in modern biology. It has become clear that a critical level of gene regulation occurs through the chemical modification of both the DNA itself and the proteins that organize eukaryotic DNA into chromatin. This form of gene regulation, termed epigenetics, refers to cellular "memory" other than the DNA sequence alone, and occurs through mechanisms such as the addition of methyl groups to DNA, as a way of marking specific genes as active or silent. The Center for Epigenetics has brought together investigators in genetics, biochemistry, cell biology, biostatistics, epidemiology, and clinical medicine to develop new technologies to apply to both basic science and population-based epigenetic studies. The center has developed several new genomics, biostatistical, and biochemical methods and is applying them to cutting-edge studies of epigenetic mechanisms and disease research.