People / Yun Liu, Ph.D


BS - Biology, Fudan University, P.R. China, 2003

MHS - Biostatistics, The Johns Hopkins University, 2007

PhD - Molecular Biology and Genetics, The Johns Hopkins University, 2009

Research Interests

The epigenetics, such as DNA methylation, may reflect age-related or environmentally mediated effects on the genome. However, it has not been defined previously or related to genetic variation. By applying a novel approach we proposed recently, we want to identify the genetic variables that are associated with epigenetic plasticity, mainly DNA methylation, thus helping us to understand the relationship between variation in DNA sequence, epigenetic marks, and phenotypes.

Areas of Research

Recognition and Leadership Roles

2009   Nupur Dinesh Thekdi Research Award, 32nd Young Investigators’ Day

The Johns Hopkins University School of Medicine.


2002, 2001, 2000      People’s Scholarship, Fudan University, China.

Selected Recent Publications

Liu, Y., Subrahmanyam, R., Chakraborty, T., Sen, R. and Desiderio, S. A Plant Homeodomain in RAG-2 that Binds Hypermethylated Lysine 4 of Histone H3 is Necessary For Efficient Antigen-Receptor-Gene Rearrangement. Immunity. (2007) 27:561-571.


Liu, Y., Zhang, L. and Desiderio, S. Temporal and Spatial Regulation of V(D)J Recombination Interactions of Extrinsic Factors with the RAG Complex. Adv. Exp. Med. Biol. (2009) 650:157-165.

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