People / Yun Liu, Ph.D
BS - Biology, Fudan University, P.R. China, 2003
MHS - Biostatistics, The Johns Hopkins University, 2007
PhD - Molecular Biology and Genetics, The Johns Hopkins University, 2009
The epigenetics, such as DNA methylation, may reflect age-related or environmentally mediated effects on the genome. However, it has not been defined previously or related to genetic variation. By applying a novel approach we proposed recently, we want to identify the genetic variables that are associated with epigenetic plasticity, mainly DNA methylation, thus helping us to understand the relationship between variation in DNA sequence, epigenetic marks, and phenotypes.
Areas of Research
Recognition and Leadership Roles
2009 Nupur Dinesh Thekdi Research Award, 32nd Young Investigators’ Day
The Johns Hopkins University School of Medicine.
2002, 2001, 2000 People’s Scholarship, Fudan University, China.
Selected Recent Publications
Liu, Y., Subrahmanyam, R., Chakraborty, T., Sen, R. and Desiderio, S. A Plant Homeodomain in RAG-2 that Binds Hypermethylated Lysine 4 of Histone H3 is Necessary For Efficient Antigen-Receptor-Gene Rearrangement. Immunity. (2007) 27:561-571.
Liu, Y., Zhang, L. and Desiderio, S. Temporal and Spatial Regulation of V(D)J Recombination Interactions of Extrinsic Factors with the RAG Complex. Adv. Exp. Med. Biol. (2009) 650:157-165.